Ta-Nehisi Coates at "The Atlantic" makes an interesting comparison between the antebellum South and Genosha, via the Wikipedia entry about the fictional Marvel Universe nation:

The island is located off the east coast of Africa, to the north of Madagascar, and boasted a high standard of living, an excellent economy, and freedom from the political and racial turmoil that characterized neighboring nations. However, Genosha's prosperity was built upon the enslavement of its mutant population.

Genosha has been more commonly seen as an allegory for apartheid South Africa, but I kind of like the idea of the "X-Tinction Agenda" storyline as the Civil War. I think this means Cameron Hodge is John Wilkes Booth and Warlock is... Abraham Lincoln?