We see relevant pop culture alphabet redecos on a pretty regular basis around these parts. Why, who could forget Sean Murphy's awesome Wolverine ABC's or Brandon and Emma Peat's "A is for Ackbar" series of Star Wars letters? It's hard to suffer from any kind of design fatigue, though, when artists like Fabian Gonzal
Remember the name Sean Murphy, because this guy is going to be big. The former "Hellblazer" artist is currently illustrating a "Joe the Barbarian" Vertigo miniseries with Grant Morrison, but more importantly to me right now, he drew this killer "Wolverine alphabet" on his Deviantart page, featuring the adamantium-clawed mutant in a variety of letter-oriented poses.
The rest of the gallery is equally can't-miss, including a charming portrait of Carl Sagan