In 53 years of publication, Fantastic Four hasn't featured a whole lot of women creators, despite having one of the most prominent superheroines, the Invisible Woman, at the heart of the team. Louise Simonson wrote the annual in 2000, and Ming Doyle drew a story in Fantastic Four #600. Marie Severin inked an annual. Several women have been colorists on the series, but a woman has never been a regular writer or artist on the book.
Perhaps that will change sometime in the next 47 years or so. There is certainly hope. The just-announced 100th Anniversary Special: Fantastic Four #1, a special issue set in 2061 boasts a creative team of highly accomplished women: writer Jen Van Meter (Hopeless Savages) and artist Joanna Estep (Fraggle Rock).